EC number:2.3.3.13

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.3 Acyl groups converted into alkyl groups on transfer
ID:2.3.3.13
Description:2-isopropylmalate synthase.
Alternative Name: Isopropylmalate synthetase.
Isopropylmalate synthase.
Alpha-isopropylmalic synthetase.
Alpha-isopropylmalate synthetase.
Alpha-isopropylmalate synthase.
Alpha-IPM synthetase.
(CoA-acetylating).
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase
Prosite: PDOC50991; PDOC00643;
PDB:
PDBScop
3U6W 8027361; 8039740; 8027361; 8039740;
3HPX 8027361; 8039740; 8027361; 8039740;
3HQ1 8027359; 8027361; 8027364; 8039738; 8039740; 8039743; 8027359; 8027361; 8027364; 8039738; 8039740; 8039743;
3HPZ 8027359; 8027361; 8027364; 8039738; 8039740; 8039743; 8027359; 8027361; 8027364; 8039738; 8039740; 8039743;
3HPS 8027359; 8027361; 8027364; 8039738; 8039740; 8039743; 8027359; 8027361; 8027364; 8039738; 8039740; 8039743;
 » show all
Cath: 1.10.1220.20; 1.10.287.140; 1.10.287.1400; 3.20.20.70; 3.30.160.270;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.3.13
BRENDA Enzyme Link: BRENDA 2.3.3.13
KEGG Enzyme Link: KEGG2.3.3.13
BioCyc Enzyme Link: BioCyc 2.3.3.13
ExPASy Enzyme Link: ExPASy2.3.3.13
EC2PDB Enzyme Link: EC2PDB 2.3.3.13
ExplorEnz Enzyme Link: ExplorEnz 2.3.3.13
PRIAM enzyme-specific profiles Link: PRIAM 2.3.3.13
IntEnz Enzyme Link: IntEnz 2.3.3.13
MEDLINE Enzyme Link: MEDLINE 2.3.3.13

EC number:2.3.3.13

MSA:

2.3.3.13;
Phylogenetic Tree:

2.3.3.13;
Uniprot:
M-CSA:
RHEA:21524 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction