EC number:2.3.3.14
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
| ID: | 2.3.3.14 | ||
|---|---|---|---|
| Description: | Homocitrate synthase. | ||
| Alternative Name: |
Homocitrate synthetase. Acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase. acetylating). 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- | ||
| Prosite: | PDOC50991; PDOC00643; | ||
| PDB: |
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| Cath: | 1.10.238.260; 1.10.287.40; 1.10.287.4050; 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.14 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.14 |
| KEGG Enzyme Link: | KEGG2.3.3.14 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.14 |
| ExPASy Enzyme Link: | ExPASy2.3.3.14 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.14 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.14 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.14 |
| RHEA:12929 | 2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. | Andi B, West AH, Cook PF | 2004 Sep 21 | 15362863 |
| Characterization of bacterial homocitrate synthase involved in lysine biosynthesis. | Wulandari AP, Miyazaki J, Kobashi N, Nishiyama M, Hoshino T, Yamane H | 2002 Jul 3 | 12095615 |