EC number:2.3.3.17
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
| ID: | 2.3.3.17 |
|---|---|
| Description: | Methylthioalkylmalate synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.17 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.17 |
| KEGG Enzyme Link: | KEGG2.3.3.17 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.17 |
| ExPASy Enzyme Link: | ExPASy2.3.3.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.17 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.17 |
| RHEA:50624 | acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis. | Textor S, de Kraker JW, Hause B, Gershenzon J, Tokuhisa JG | 2007 May | 17369439 |
| Glucosinolate and amino acid biosynthesis in Arabidopsis. | Field B, Cardon G, Traka M, Botterman J, Vancanneyt G, Mithen R | 2004 Jun | 15155874 |
| Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. | Falk KL, Vogel C, Textor S, Bartram S, Hick A, Pickett JA, Gershenzon J | 2004 Apr | 15110687 |
| Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle. | Textor S, Bartram S, Kroymann J, Falk KL, Hick A, Pickett JA, Gershenzon J | 2004 Apr | 14740211 |
| RHEA:25605 | 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis. | Textor S, de Kraker JW, Hause B, Gershenzon J, Tokuhisa JG | 2007 May | 17369439 |
| Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. | Falk KL, Vogel C, Textor S, Bartram S, Hick A, Pickett JA, Gershenzon J | 2004 Apr | 15110687 |
| RHEA:25601 | 4-(methylsulfanyl)-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis. | Textor S, de Kraker JW, Hause B, Gershenzon J, Tokuhisa JG | 2007 May | 17369439 |
| Glucosinolate and amino acid biosynthesis in Arabidopsis. | Field B, Cardon G, Traka M, Botterman J, Vancanneyt G, Mithen R | 2004 Jun | 15155874 |
| Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. | Falk KL, Vogel C, Textor S, Bartram S, Hick A, Pickett JA, Gershenzon J | 2004 Apr | 15110687 |
| Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle. | Textor S, Bartram S, Kroymann J, Falk KL, Hick A, Pickett JA, Gershenzon J | 2004 Apr | 14740211 |