EC number:2.3.3.19
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
| ID: | 2.3.3.19 |
|---|---|
| Description: | 2-phosphonomethylmalate synthase. |
| Alternative Name: |
PMM synthase. 2-phosphinomethylmalic acid synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.19 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.19 |
| KEGG Enzyme Link: | KEGG2.3.3.19 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.19 |
| ExPASy Enzyme Link: | ExPASy2.3.3.19 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.19 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.19 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.19 |
| RHEA:52144 | 3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies on the biosynthesis of bialaphos (SE-1293). 7. The absolute configuration of 2-phosphinomethylmalic acid, a biosynthetic intermediate of bialaphos. | Shimotohno K, Seto H, Otake N, Imai S, Satoh A | 1986 Sep | 3781934 |
| Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. | Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW | 2008 Aug 25 | 18721747 |
| Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293. | Shimotohno KW, Seto H, Otake N, Imai S, Murakami T | 1988 Aug | 3170341 |