EC number:2.3.3.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
| ID: | 2.3.3.5 | ||
|---|---|---|---|
| Description: | 2-methylcitrate synthase. | ||
| Alternative Name: |
Methylcitrate synthetase. Methylcitrate synthase. MCS. 2-methylcitrate oxaloacetate-lyase. | ||
| Prosite: | PDOC00422; | ||
| PDB: |
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| Cath: | 1.10.230.10; 1.10.580.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.5 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.5 |
| KEGG Enzyme Link: | KEGG2.3.3.5 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.5 |
| ExPASy Enzyme Link: | ExPASy2.3.3.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.5 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.5 |
| RHEA:23780 | H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH2;+0:7]-[*:8])-[S;H0;+0:9]-[*:10].[OH2;+0:11]>>[*:10]-[SH;+0:9].[*:5]=[C;H0;+0:6](-[OH;+0:11])-[CH;+0:7](-[*:8])-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. | Gerike U, Hough DW, Russell NJ, Dyall-Smith ML, Danson MJ | 1998 Apr | 9579066 |
| Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. | Textor S, Wendisch VF, De Graaf AA, Müller U, Linder MI, Linder D, Buckel W | 1997 Nov | 9325432 |
| Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources. | Domin N, Wilson D, Brock M | 2009 Dec | 19661181 |
| Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase. | Brock M, Maerker C, Schütz A, Völker U, Buckel W | 2002 Dec | 12473114 |
| Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle. | Claes WA, Pühler A, Kalinowski J | 2002 May | 11976302 |
| The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism. | Brämer CO, Steinbüchel A | 2001 Aug | 11495997 |
| Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. | Horswill AR, Escalante-Semerena JC | 1999 Sep | 10482501 |