EC number:2.3.3.6

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.3 Acyl groups converted into alkyl groups on transfer
ID:2.3.3.6
Description:2-ethylmalate synthase.
Alternative Name: Propylmalic synthase.
Propylmalate synthase.
2-ethylmalate-3-hydroxybutanedioate synthase.
(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating).

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.3.6
BRENDA Enzyme Link: BRENDA 2.3.3.6
KEGG Enzyme Link: KEGG2.3.3.6
BioCyc Enzyme Link: BioCyc 2.3.3.6
ExPASy Enzyme Link: ExPASy2.3.3.6
EC2PDB Enzyme Link: EC2PDB 2.3.3.6
ExplorEnz Enzyme Link: ExplorEnz 2.3.3.6
PRIAM enzyme-specific profiles Link: PRIAM 2.3.3.6
IntEnz Enzyme Link: IntEnz 2.3.3.6
MEDLINE Enzyme Link: MEDLINE 2.3.3.6

EC number:2.3.3.6

MSA:

2.3.3.6;
Phylogenetic Tree:

2.3.3.6;
Uniprot:
M-CSA:
RHEA:23040 2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A study of acetyl-CoA condensation with alpha-keto acids.Strassman M, Ceci LN1967 Mar6052435