EC number:2.3.3.8

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.3 Acyl groups converted into alkyl groups on transfer
ID:2.3.3.8
Description:ATP citrate synthase.
Alternative Name: Citric cleavage enzyme.
Citrate-ATP lyase.
Citrate cleavage enzyme.
dephosphorylating).
ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP-
ATP-citric lyase.
ATP-citrate (pro-S-)-lyase.
ATP citrate (pro-S)-lyase.
Adenosine triphosphate citrate lyase.
phosphorylating).
Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-
Prosite: PDOC00335;
PDB:
PDBScop
5CAE 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
4XX0 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
2FPP 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
2FPG 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
2FP4 8058549; 8058550; 8058551; 8058552; 8057674; 8057675; 8057676; 8057677;
 » show all
Cath: 3.30.1490.20; 3.30.470.110; 3.30.470.20; 3.40.50.720; 3.40.50.261;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.3.8
BRENDA Enzyme Link: BRENDA 2.3.3.8
KEGG Enzyme Link: KEGG2.3.3.8
BioCyc Enzyme Link: BioCyc 2.3.3.8
ExPASy Enzyme Link: ExPASy2.3.3.8
EC2PDB Enzyme Link: EC2PDB 2.3.3.8
ExplorEnz Enzyme Link: ExplorEnz 2.3.3.8
PRIAM enzyme-specific profiles Link: PRIAM 2.3.3.8
IntEnz Enzyme Link: IntEnz 2.3.3.8
MEDLINE Enzyme Link: MEDLINE 2.3.3.8

EC number:2.3.3.8

MSA:

2.3.3.8;
Phylogenetic Tree:

2.3.3.8;
Uniprot:
M-CSA:
RHEA:21160 acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[OH;+0:6].[*:7]=[C;H0;+0:8](-[CH3;+0:9])-[S;H0;+0:10]-[*:11].[*:12]=[P;H0;+0:13](-[*:14])(-[*:15])-[OH;+0:16]>>[*:5]-[O;H0;+0:6]-[P;H0;+0:13](=[*:12])(-[*:14])-[*:15].[*:11]-[SH;+0:10].[*:7]=[C;H0;+0:8](-[OH;+0:16])-[CH2;+0:9]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PHE, Steinberg GR, Lalwani ND2016 Nov 2827892461
Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus.Zhang H, Zhang L, Chen H, Chen YQ, Chen W, Song Y, Ratledge C2014 Dec 2025450640
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY2013 Aug 2223932781
A novel direct homogeneous assay for ATP citrate lyase.Ma Z, Chu CH, Cheng D2009 Oct19286649