EC number:2.3.3.9
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
| ID: | 2.3.3.9 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description: | Malate synthase. | ||||||||
| Alternative Name: |
Malic-condensing enzyme. Malic synthetase. Malate synthetase. Malate condensing enzyme. L-malate glyoxylate-lyase (CoA-acetylating). Glyoxylic transacetase. Glyoxylate transacetylase. Glyoxylate transacetase. | ||||||||
| Prosite: | PDOC00441; | ||||||||
| PDB: |
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| Cath: | 1.20.1220.12; 3.20.20.360; 3.20.20.60; 1.20.58.1560; 2.170.170.11; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.9 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.9 |
| KEGG Enzyme Link: | KEGG2.3.3.9 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.9 |
| ExPASy Enzyme Link: | ExPASy2.3.3.9 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.9 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.9 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.9 |
| RHEA:18181 | acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]=[C;H0;+0:5](-[CH3;+0:6])-[S;H0;+0:7]-[*:8].[OH2;+0:9]>>[*:8]-[SH;+0:7].[*:4]=[C;H0;+0:5](-[OH;+0:9])-[CH2;+0:6]-[CH;+0:2](-[*:1])-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular characterization of Escherichia coli malate synthase G. Differentiation with the malate synthase A isoenzyme. | Molina I, Pellicer MT, Badia J, Aguilar J, Baldoma L | 1994 Sep 1 | 7925370 |
| Purification and properties of malate synthetase. | DIXON GH, KORNBERG HL, LUND P | 1960 Jul 1 | 13816984 |
| Structure of the Escherichia coli malate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 A resolution. | Anstrom DM, Kallio K, Remington SJ | 2003 Sep | 12930982 |
| Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis. | Smith CV, Huang CC, Miczak A, Russell DG, Sacchettini JC, Höner zu Bentrup K | 2003 Jan 17 | 12393860 |