EC number:2.4.1.109
| ID: | 2.4.1.109 |
|---|---|
| Description: | Dolichyl-phosphate-mannose--protein mannosyltransferase. |
| Alternative Name: |
Dolichyl-phosphate-mannose-protein mannosyltransferase. Dolichol phosphomannose-protein mannosyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.109 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.109 |
| KEGG Enzyme Link: | KEGG2.4.1.109 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.109 |
| ExPASy Enzyme Link: | ExPASy2.4.1.109 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.109 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.109 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.109 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.109 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.109 |
EC number:2.4.1.109
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:53396 | dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = dolichyl phosphate + H(+) + O(3)-(alpha-D-mannosyl)-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. | Gentzsch M, Tanner W | 1997 Jun | 9184828 |
| Protein O-glycosylation in Saccharomyces cerevisiae: the protein O-mannosyltransferases Pmt1p and Pmt2p function as heterodimer. | Gentzsch M, Immervoll T, Tanner W | 1995 Dec 18 | 8543034 |
| PMT1, the gene for a key enzyme of protein O-glycosylation in Saccharomyces cerevisiae. | Strahl-Bolsinger S, Immervoll T, Deutzmann R, Tanner W | 1993 Sep 1 | 8367478 |
| Protein O-mannosylation: what we have learned from baker's yeast. | Loibl M, Strahl S | 2013 Nov | 23434682 |
| O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae. | Hirayama H, Fujita M, Yoko-o T, Jigami Y | 2008 Apr | 18182384 |
| Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases. | Hutzler J, Schmid M, Bernard T, Henrissat B, Strahl S | 2007 May 8 | 17470820 |
| PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance. | Prill SK, Klinkert B, Timpel C, Gale CA, Schröppel K, Ernst JF | 2005 Jan | 15659169 |
| Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity. | Manya H, Chiba A, Yoshida A, Wang X, Chiba Y, Jigami Y, Margolis RU, Endo T | 2004 Jan 13 | 14699049 |
| Structure-function analysis of the dolichyl phosphate-mannose: protein O-mannosyltransferase ScPmt1p. | Girrbach V, Zeller T, Priesmeier M, Strahl-Bolsinger S | 2000 Jun 23 | 10764776 |
| RHEA:17377 | dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = dolichyl phosphate + H(+) + O(3)-(alpha-D-mannosyl)-L-seryl-[protein] |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. | Gentzsch M, Tanner W | 1997 Jun | 9184828 |
| Protein O-glycosylation in Saccharomyces cerevisiae: the protein O-mannosyltransferases Pmt1p and Pmt2p function as heterodimer. | Gentzsch M, Immervoll T, Tanner W | 1995 Dec 18 | 8543034 |
| PMT1, the gene for a key enzyme of protein O-glycosylation in Saccharomyces cerevisiae. | Strahl-Bolsinger S, Immervoll T, Deutzmann R, Tanner W | 1993 Sep 1 | 8367478 |
| Protein O-mannosylation: what we have learned from baker's yeast. | Loibl M, Strahl S | 2013 Nov | 23434682 |
| O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae. | Hirayama H, Fujita M, Yoko-o T, Jigami Y | 2008 Apr | 18182384 |
| Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases. | Hutzler J, Schmid M, Bernard T, Henrissat B, Strahl S | 2007 May 8 | 17470820 |
| PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance. | Prill SK, Klinkert B, Timpel C, Gale CA, Schröppel K, Ernst JF | 2005 Jan | 15659169 |
| Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity. | Manya H, Chiba A, Yoshida A, Wang X, Chiba Y, Jigami Y, Margolis RU, Endo T | 2004 Jan 13 | 14699049 |
| Structure-function analysis of the dolichyl phosphate-mannose: protein O-mannosyltransferase ScPmt1p. | Girrbach V, Zeller T, Priesmeier M, Strahl-Bolsinger S | 2000 Jun 23 | 10764776 |