EC number:2.4.1.258

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.258
Description:Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase.
Alternative Name: Man(5)GlcNAc(2)-PP-Dol mannosyltransferase.
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase.
Alg3 alpha-1,3-mannosyl transferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.258
BRENDA Enzyme Link: BRENDA 2.4.1.258
KEGG Enzyme Link: KEGG2.4.1.258
BioCyc Enzyme Link: BioCyc 2.4.1.258
ExPASy Enzyme Link: ExPASy2.4.1.258
EC2PDB Enzyme Link: EC2PDB 2.4.1.258
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.258
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.258
IntEnz Enzyme Link: IntEnz 2.4.1.258
MEDLINE Enzyme Link: MEDLINE 2.4.1.258

EC number:2.4.1.258

MSA:

2.4.1.258;
Phylogenetic Tree:

2.4.1.258;
Uniprot:
M-CSA:
RHEA:29527 alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
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References

TitleAuthorsDatePubMed ID
Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing.Henquet M, Lehle L, Schreuder M, Rouwendal G, Molthoff J, Helsper J, van der Krol S, Bosch D2008 Jun18567790
Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.Sharma CB, Knauer R, Lehle L2001 Feb11308030
The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing.Cipollo JF, Trimble RB2000 Feb 1110660594