EC number:2.4.1.259
| ID: | 2.4.1.259 |
|---|---|
| Description: | Dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase. |
| Alternative Name: |
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.259 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.259 |
| KEGG Enzyme Link: | KEGG2.4.1.259 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.259 |
| ExPASy Enzyme Link: | ExPASy2.4.1.259 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.259 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.259 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.259 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.259 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.259 |
EC number:2.4.1.259
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:29531 | alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis. | Hong Z, Jin H, Fitchette AC, Xia Y, Monk AM, Faye L, Li J | 2009 Dec | 20023196 |
| ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis. | Frank CG, Aebi M | 2005 Nov | 15987956 |
| CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features. | Weinstein M, Schollen E, Matthijs G, Neupert C, Hennet T, Grubenmann CE, Frank CG, Aebi M, Clarke JT, Griffiths A, Seargeant L, Poplawski N | 2005 Jul 15 | 15945070 |
| Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL. | Frank CG, Grubenmann CE, Eyaid W, Berger EG, Aebi M, Hennet T | 2004 Jul | 15148656 |
| The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing. | Cipollo JF, Trimble RB | 2000 Feb 11 | 10660594 |