EC number:2.4.1.274
| ID: | 2.4.1.274 |
|---|---|
| Description: | Glucosylceramide beta-1,4-galactosyltransferase. |
| Alternative Name: |
Lactosylceramide synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.274 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.274 |
| KEGG Enzyme Link: | KEGG2.4.1.274 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.274 |
| ExPASy Enzyme Link: | ExPASy2.4.1.274 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.274 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.274 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.274 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.274 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.274 |
EC number:2.4.1.274
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:31495 | a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. | Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Fururkawa K, Ito M, Asano M | 2018 Aug | 30114188 |
| Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. | Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N | 1998 May 29 | 9593693 |
| UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. | Chatterjee S, Castiglione E | 1987 Jan 20 | 3099851 |
| Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis. | Kumagai T, Sato T, Natsuka S, Kobayashi Y, Zhou D, Shinkai T, Hayakawa S, Furukawa K | 2010 Oct | 21057870 |
| Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. | Chatterjee S, Ghosh N, Khurana S | 1992 Apr 5 | 1551920 |
| cDNA cloning and expression of human lactosylceramide synthase. | Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N | 1999 May 18 | 10320813 |