EC number:2.4.2.28
| ID: | 2.4.2.28 | ||
|---|---|---|---|
| Description: | S-methyl-5'-thioadenosine phosphorylase. | ||
| Alternative Name: |
MTAPase. MTA phosphorylase. Methylthioadenosine phosphorylase. Methylthioadenosine nucleoside phosphorylase. MeSAdo/Ado phosphorylase. MeSAdo phosphorylase. 5'-methylthioadenosine phosphorylase. 5'-deoxy-5'-methylthioadenosine phosphorylase. | ||
| Prosite: | PDOC00946; PDOC00954; | ||
| PDB: |
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| Cath: | 3.40.50.1580; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.28 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.28 |
| KEGG Enzyme Link: | KEGG2.4.2.28 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.28 |
| ExPASy Enzyme Link: | ExPASy2.4.2.28 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.28 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.28 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.28 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.28 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.28 |
| RHEA:24869 | 5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]:[n;H0;+0:4](:[*:5])-[CH;+0:6](-[*:7])-[*:8]>>[*:1]-[O;H0;+0:2]-[CH;+0:6](-[*:7])-[*:8].[*:3]:[nH;+0:4]:[*:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 5'-Methylthioadenosine phosphorylase-L. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells. | Savarese TM, Crabtree GW, Parks RE Jr | 1981 Feb 1 | 6164373 |
| RHEA:11852 | phosphate + S-methyl-5'-thioadenosine = 5-methylsulfanyl-alpha-D-ribose 1-phosphate + adenine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]:[n;H0;+0:4](:[*:5])-[CH;+0:6](-[*:7])-[*:8]>>[*:1]-[O;H0;+0:2]-[CH;+0:6](-[*:7])-[*:8].[*:3]:[nH;+0:4]:[*:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate. | Pegg AE, Williams-Ashman HG | 1969 Nov | 5378381 |
| Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung. | Garbers DL | 1978 Mar 14 | 415762 |
| Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis. | Buckoreelall K, Sun Y, Hobrath JV, Wilson L, Parker WB | 2012 Mar | 22225784 |
| 5'-Methylthioadenosine phosphorylase from Caldariella acidophila. Purification and properties. | Carteni'-Farina M, Oliva A, Romeo G, Napolitano G, De Rosa M, Gambacorta A, Zappia V | 1979 Nov | 118001 |