EC number:2.4.2.29
| ID: | 2.4.2.29 |
|---|---|
| Description: | tRNA-guanine(34) transglycosylase. |
| Alternative Name: |
tRNA transglycosylase. tRNA guanine(34) transglycosidase. TGT. Queuine(34) transfer ribonucleate ribosyltransferase. Queuine tRNA-ribosyltransferase. Q-insertase. Guanine insertion enzyme. |
| Cath: | 3.20.20.10; 3.20.20.105; 3.30.1130.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.29 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.29 |
| KEGG Enzyme Link: | KEGG2.4.2.29 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.29 |
| ExPASy Enzyme Link: | ExPASy2.4.2.29 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.29 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.29 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.29 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.29 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.29 |
| RHEA:24104 | 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine |
| RULE(radius=1) | [*:1]:[n;H0;+0:2](:[*:3])-[CH;+0:4](-[*:5])-[*:6].[*:7]:[nH;+0:8]:[*:9]>>[*:7]:[n;H0;+0:8](:[*:9])-[CH;+0:4](-[*:5])-[*:6].[*:1]:[nH;+0:2]:[*:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction. | Okada N, Noguchi S, Kasai H, Shindo-Okada N, Ohgi T, Goto T, Nishimura S | 1979 Apr 25 | 372186 |
| Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity. | Todorov KA, Garcia GA | 2006 Jan 17 | 16401090 |
| Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. | Boland C, Hayes P, Santa-Maria I, Nishimura S, Kelly VP | 2009 Jul 3 | 19414587 |
| RHEA:16633 | guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA |
| RULE(radius=1) | [*:1]:[n;H0;+0:2](:[*:3])-[CH;+0:4](-[*:5])-[*:6].[*:7]:[nH;+0:8]:[*:9]>>[*:7]:[n;H0;+0:8](:[*:9])-[CH;+0:4](-[*:5])-[*:6].[*:1]:[nH;+0:2]:[*:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA. | Howes NK, Farkas WR | 1978 Dec 25 | 721832 |
| Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction. | Okada N, Noguchi S, Kasai H, Shindo-Okada N, Ohgi T, Goto T, Nishimura S | 1979 Apr 25 | 372186 |
| Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity. | Todorov KA, Garcia GA | 2006 Jan 17 | 16401090 |