EC number:2.4.2.43
| ID: | 2.4.2.43 |
|---|---|
| Description: | Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase. |
| Alternative Name: |
Undecaprenyl phosphate-alpha-L-Ara4N transferase. transferase. Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl Polymyxin resistance protein PmrK. Lipid A 4-amino-4-deoxy-L-arabinosyltransferase. 4-amino-4-deoxy-L-arabinose lipid A transferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.43 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.43 |
| KEGG Enzyme Link: | KEGG2.4.2.43 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.43 |
| ExPASy Enzyme Link: | ExPASy2.4.2.43 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.43 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.43 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.43 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.43 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.43 |
| RHEA:35371 | 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[O;H0;+0:7]-[CH;+0:8](-[*:9])-[*:10].([*:11]-[OH;+0:12].[*:13]-[OH;+0:14])>>([*:11]-[O;H0;+0:12]-[CH;+0:3](-[*:4])-[*:5].[*:13]-[O;H0;+0:14]-[CH;+0:8](-[*:9])-[*:10]).[*:1]-[OH;+0:2].[*:6]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. | Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR | 2005 Apr 8 | 15695810 |
| An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. | Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR | 2001 Nov 16 | 11535604 |
| RHEA:27730 | 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. | Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CR | 2001 Nov 16 | 11535605 |
| An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. | Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR | 2001 Nov 16 | 11535604 |