EC number:2.4.2.45
| ID: | 2.4.2.45 |
|---|---|
| Description: | Decaprenyl-phosphate phosphoribosyltransferase. |
| Alternative Name: |
DPPR synthase. 5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase. 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.45 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.45 |
| KEGG Enzyme Link: | KEGG2.4.2.45 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.45 |
| ExPASy Enzyme Link: | ExPASy2.4.2.45 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.45 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.45 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.45 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.45 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.45 |
| RHEA:34067 | 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7].[H+;H0:8]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. | Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST | 2009 May 8 | 19299584 |
| Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis. | Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR | 2005 Jul 1 | 15878857 |