EC number:2.4.2.59

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.2 Pentosyltransferases
ID:2.4.2.59
Description:Sulfide-dependent adenosine diphosphate thiazole synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.2.59
BRENDA Enzyme Link: BRENDA 2.4.2.59
KEGG Enzyme Link: KEGG2.4.2.59
BioCyc Enzyme Link: BioCyc 2.4.2.59
ExPASy Enzyme Link: ExPASy2.4.2.59
EC2PDB Enzyme Link: EC2PDB 2.4.2.59
ExplorEnz Enzyme Link: ExplorEnz 2.4.2.59
PRIAM enzyme-specific profiles Link: PRIAM 2.4.2.59
IntEnz Enzyme Link: IntEnz 2.4.2.59
MEDLINE Enzyme Link: MEDLINE 2.4.2.59

EC number:2.4.2.59

MSA:

2.4.2.59;
Phylogenetic Tree:

2.4.2.59;
Uniprot:
M-CSA:
RHEA:55704 glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide
RULE(radius=1) [*:1]-[CH2;+0:2]-[NH2;+0:3].[*:4]-[CH;+0:5]1-[O;H0;+0:6]-[CH;+0:7](-[n+;H0:8](:[*:9]):[*:10])-[CH;+0:11](-[OH;+0:12])-[CH;+0:13]-1-[OH;+0:14].[SH2;+0:15]>>[*:4]-[CH2;+0:5]-[c;H0;+0:13]1:[s;H0;+0:15]:[c;H0;+0:2](-[*:1]):[n;H0;+0:3]:[c;H0;+0:11]:1-[CH3;+0:7].[*:9]:[n;H0;+0:8]:[*:10].[OH2;+0:14].[OH2;+0:12].[OH2;+0:6]
Reaction
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References

TitleAuthorsDatePubMed ID
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE2016 Mar 2326928142
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE2016 Mar 2926919468