EC number:2.4.2.8
| ID: | 2.4.2.8 | ||
|---|---|---|---|
| Description: | Hypoxanthine phosphoribosyltransferase. | ||
| Alternative Name: |
Transphosphoribosidase. IMP pyrophosphorylase. IMP diphosphorylase. Hypoxanthine-guanine phosphoribosyltransferase. HGPRTase. Guanine phosphoribosyltransferase. | ||
| Prosite: | PDOC00096; | ||
| PDB: |
|
||
| Cath: | 3.40.50.20; 3.40.50.2020; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.8 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.8 |
| KEGG Enzyme Link: | KEGG2.4.2.8 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.8 |
| ExPASy Enzyme Link: | ExPASy2.4.2.8 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.8 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.8 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.8 |
| RHEA:25424 | diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[n;H0;+0:4](:[*:5]):[*:6].[*:7]-[OH;+0:8]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:8]-[*:7].[*:5]:[nH;+0:4]:[*:6] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants. | Breton A, Pinson B, Coulpier F, Giraud MF, Dautant A, Daignan-Fornier B | 2008 Feb | 18245832 |
| Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex. | Héroux A, White EL, Ross LJ, Borhani DW | 1999 Nov 2 | 10545170 |
| RHEA:17973 | diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[n;H0;+0:4]1:[*:5]:[*:6]:[n;H0;+0:7]:[*:8]:1.[*:9]-[OH;+0:10]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:10]-[*:9].[*:5]1:[*:6]:[nH;+0:7]:[*:8]:[n;H0;+0:4]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants. | Breton A, Pinson B, Coulpier F, Giraud MF, Dautant A, Daignan-Fornier B | 2008 Feb | 18245832 |
| Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. | Guddat LW, Vos S, Martin JL, Keough DT, de Jersey J | 2002 Jul | 12070315 |