EC number:2.4.99.18
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.18 | ||
|---|---|---|---|
| Description: | Dolichyl-diphosphooligosaccharide--protein glycotransferase. | ||
| Prosite: | PDOC00172; | ||
| PDB: |
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| Cath: | 1.20.58.1650; 3.40.30.10; 3.40.50.12610; 2.60.40.3390; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.18 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.18 |
| KEGG Enzyme Link: | KEGG2.4.99.18 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.18 |
| ExPASy Enzyme Link: | ExPASy2.4.99.18 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.18 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.18 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.18 |
EC number:2.4.99.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50348 | alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[NH2;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[NH;+0:7]-[*:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dolichyldiphosphoryloligosaccharide--protein oligosaccharyltransferase; solubilization, purification, and properties. | Das RC, Heath EC | 1980 Jul | 6933437 |
| N-glycoproteomics in plants: perspectives and challenges. | Song W, Henquet MG, Mentink RA, van Dijk AJ, Cordewener JH, Bosch D, America AH, van der Krol AR | 2011 Aug 12 | 21605711 |
| RHEA:22980 | a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[NH2;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[NH;+0:7]-[*:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dolichyldiphosphoryloligosaccharide--protein oligosaccharyltransferase; solubilization, purification, and properties. | Das RC, Heath EC | 1980 Jul | 6933437 |
| N-glycoproteomics in plants: perspectives and challenges. | Song W, Henquet MG, Mentink RA, van Dijk AJ, Cordewener JH, Bosch D, America AH, van der Krol AR | 2011 Aug 12 | 21605711 |