EC number:2.5.1.1

Enzyme

Download
EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.1
Description:Dimethylallyltranstransferase.
Alternative Name: Prenyltransferase.
Geranyl-diphosphate synthase.
Dimethylallyltransferase.
Prosite: PDOC00407;
PDB:
PDBScop
1RQJ 8028463; 8040842; 8028463; 8040842;
1RQI 8028463; 8040842; 8028463; 8040842;
1UBY 8026470; 8038849;
1UBX 8026470; 8038849;
1UBW 8026470; 8038849;
 » show all
Cath: 1.10.600.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.1
BRENDA Enzyme Link: BRENDA 2.5.1.1
KEGG Enzyme Link: KEGG2.5.1.1
BioCyc Enzyme Link: BioCyc 2.5.1.1
ExPASy Enzyme Link: ExPASy2.5.1.1
EC2PDB Enzyme Link: EC2PDB 2.5.1.1
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.1
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.1
IntEnz Enzyme Link: IntEnz 2.5.1.1
MEDLINE Enzyme Link: MEDLINE 2.5.1.1

EC number:2.5.1.1

MSA:

2.5.1.1;
Phylogenetic Tree:

2.5.1.1;
Uniprot:
M-CSA:
RHEA:22408 dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[C;H0;+0:3](-[*:4])=[CH2;+0:5].[*:6]-[CH2;+0:7]-[O;H0;+0:8]-[*:9]>>[*:6]-[CH2;+0:7]-[CH2;+0:5]-[C;H0;+0:3](-[*:4])=[CH;+0:2]-[*:1].[*:9]-[OH;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U2006 Aug 416698791
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U2006 May 1616684881