EC number:2.5.1.10

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.10
Description:(2E,6E)-farnesyl diphosphate synthase.
Alternative Name: Geranyltranstransferase.
FPP synthetase.
Farnesyl-diphosphate synthase.
Farnesyl pyrophosphate synthetase.
Prosite: PDOC00407;
PDB:
PDBScop
Cath: 1.10.600.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.10
BRENDA Enzyme Link: BRENDA 2.5.1.10
KEGG Enzyme Link: KEGG2.5.1.10
BioCyc Enzyme Link: BioCyc 2.5.1.10
ExPASy Enzyme Link: ExPASy2.5.1.10
EC2PDB Enzyme Link: EC2PDB 2.5.1.10
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.10
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.10
IntEnz Enzyme Link: IntEnz 2.5.1.10
MEDLINE Enzyme Link: MEDLINE 2.5.1.10

EC number:2.5.1.10

MSA:

2.5.1.10;
Phylogenetic Tree:

2.5.1.10;
Uniprot:
M-CSA:
RHEA:19361 (2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
RULE(radius=1) [C:1]([CH3:2])=[C:3][C:4][O:0].[CH2:5]=[C:6]([CH3:7])[C:8][C:9][O:10][P:11](=[O:12])([O:13])[O:14]>>[C:1]([CH3:2])=[C:3][C:4][CH2:5][C:6]([CH3:7])=[C:8][C:9][O:0].[O:10][P:11](=[O:12])([O:13])[O:14]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.Sheares BT, White SS, Molowa DT, Chan K, Ding VD, Kroon PA, Bostedor RG, Karkas JD1989 Oct 32690933
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U2006 May 1616684881
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.Dhiman RK, Schulbach MC, Mahapatra S, Baulard AR, Vissa V, Brennan PJ, Crick DC2004 Jun15060088