EC number:2.5.1.103
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.103 |
|---|---|
| Description: | Presqualene diphosphate synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.103 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.103 |
| KEGG Enzyme Link: | KEGG2.5.1.103 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.103 |
| ExPASy Enzyme Link: | ExPASy2.5.1.103 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.103 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.103 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.103 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.103 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.103 |
EC number:2.5.1.103
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:22672 | 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[*:9]>>[*:1]-[CH;+0:2]1-[CH;+0:6](-[*:5])-[C;H0;+0:7]-1(-[*:8])-[*:9].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural insights into the catalytic mechanism of human squalene synthase. | Liu CI, Jeng WY, Chang WJ, Shih MF, Ko TP, Wang AH | 2014 Feb | 24531458 |
| Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. | Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J | 2011 Jul 26 | 21746901 |
| Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway. | Ku B, Jeong JC, Mijts BN, Schmidt-Dannert C, Dordick JS | 2005 Nov | 16269684 |
| Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus. | Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Götz F | 2005 Sep 16 | 16020541 |
| Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. | Umeno D, Tobias AV, Arnold FH | 2002 Dec | 12426357 |
| Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. | Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr | 2000 Sep 29 | 10896663 |