EC number:2.5.1.108

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.108
Description:2-(3-amino-3-carboxypropyl)histidine synthase.
Cath: 3.40.50.11840; 3.40.50.11850; 3.40.50.11860;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.108
BRENDA Enzyme Link: BRENDA 2.5.1.108
KEGG Enzyme Link: KEGG2.5.1.108
BioCyc Enzyme Link: BioCyc 2.5.1.108
ExPASy Enzyme Link: ExPASy2.5.1.108
EC2PDB Enzyme Link: EC2PDB 2.5.1.108
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.108
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.108
IntEnz Enzyme Link: IntEnz 2.5.1.108
MEDLINE Enzyme Link: MEDLINE 2.5.1.108

EC number:2.5.1.108

MSA:

2.5.1.108;
Phylogenetic Tree:

2.5.1.108;
Uniprot:
M-CSA:
RHEA:36783 L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]1:[*:7]:[nH;+0:8]:[cH;+0:9]:[n;H0;+0:10]:1>>[*:5]-[CH2;+0:4]-[c;H0;+0:9]1:[n;H0;+0:8]:[*:7]:[*:6]:[nH;+0:10]:1.[*:1]-[S;H0;+0:2]-[*:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis.Zhu X, Dzikovski B, Su X, Torelli AT, Zhang Y, Ealick SE, Freed JH, Lin H2011 Jan20931132
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H2010 Jun 1720559380
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH2004 Nov15485916