EC number:2.5.1.113

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.113
Description:synthase.
Alternative Name: CysO-thiocarboxylate-dependent cysteine synthase.
Cath: 3.40.50.1100;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.113
BRENDA Enzyme Link: BRENDA 2.5.1.113
KEGG Enzyme Link: KEGG2.5.1.113
BioCyc Enzyme Link: BioCyc 2.5.1.113
ExPASy Enzyme Link: ExPASy2.5.1.113
EC2PDB Enzyme Link: EC2PDB 2.5.1.113
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.113
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.113
IntEnz Enzyme Link: IntEnz 2.5.1.113
MEDLINE Enzyme Link: MEDLINE 2.5.1.113

EC number:2.5.1.113

MSA:

2.5.1.113;
Phylogenetic Tree:

2.5.1.113;
Uniprot:
M-CSA:
RHEA:48740 [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[SH;+0:6]>>[*:4]-[OH;+0:3].[*:5]-[S;H0;+0:6]-[CH2;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity.Agren D, Schnell R, Schneider G2009 Jan 2219101553
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.O'Leary SE, Jurgenson CT, Ealick SE, Begley TP2008 Nov 418842002
Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.Agren D, Schnell R, Oehlmann W, Singh M, Schneider G2008 Nov 1418799456
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.Jurgenson CT, Burns KE, Begley TP, Ealick SE2008 Sep 3018771296