EC number:2.5.1.120
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.120 |
|---|---|
| Description: | Aminodeoxyfutalosine synthase. |
| Alternative Name: |
Aminofutalosine synthase. AFL synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.120 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.120 |
| KEGG Enzyme Link: | KEGG2.5.1.120 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.120 |
| ExPASy Enzyme Link: | ExPASy2.5.1.120 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.120 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.120 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.120 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.120 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.120 |
EC number:2.5.1.120
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33075 | 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[S+;H0:3](-[*:4])-[*:5].[*:6]=[C;H0;+0:7](-[*:8])-[OH;+0:9]).[*:10]=[C;H0;+0:11](-[*:12])-[C;H0;+0:13](=[CH2;+0:14])-[O;H0;+0:15]-[c;H0;+0:16](:[*:17]):[*:18]:[*:19]-[C;H0;+0:20](=[*:21])-[OH;+0:22].[OH2;+0:23]>>[*:1]-[CH2;+0:2]-[CH2;+0:14]-[C;H0;+0:13](=[O;H0;+0:15])-[c;H0;+0:16](:[*:17]):[*:18]:[*:19]-[C;H0;+0:20](=[*:21])-[OH;+0:9].([*:4]-[S;H0;+0:3]-[*:5].[*:6]=[C;H0;+0:7](-[*:8])-[OH;+0:23]).[*:10]=[C;H0;+0:11](-[*:12])-[OH;+0:22] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. | Mahanta N, Fedoseyenko D, Dairi T, Begley TP | 2013 Oct 16 | 24083939 |
| 5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni. | Li X, Apel D, Gaynor EC, Tanner ME | 2011 Jun 3 | 21489995 |
| Diversity of the early step of the futalosine pathway. | Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T | 2011 Feb | 21098241 |
| An alternative menaquinone biosynthetic pathway operating in microorganisms. | Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T | 2008 Sep 19 | 18801996 |