EC number:2.5.1.132
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.132 |
|---|---|
| Description: | 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase. |
| Alternative Name: |
KDN 9-P synthase. 2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.132 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.132 |
| KEGG Enzyme Link: | KEGG2.5.1.132 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.132 |
| ExPASy Enzyme Link: | ExPASy2.5.1.132 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.132 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.132 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.132 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.132 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.132 |
EC number:2.5.1.132
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:49200 | D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[*:5].[*:6]-[CH;+0:7](-[*:8]-[*:9]-[OH;+0:10])-[O;H0;+0:11]-[*:12].[OH2;+0:13]>>([*:6]-[CH;+0:7]1-[*:8]-[*:9]-[O;H0;+0:10]-[C;H0;+0:2](-[*:1])(-[OH;+0:13])-[CH2;+0:3]-1.[*:12]-[OH;+0:11]).[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN). | Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D | 2008 Sep 22 | 18804026 |
| Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability. | Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ | 2000 Jun 9 | 10749855 |
| Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis. | Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd | 1999 Aug 13 | 10438460 |