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2. Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

ID:	2.5.1.141
Description:	Heme o synthase.

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UniProtKB Enzyme Link:	UniProtKB 2.5.1.141
BRENDA Enzyme Link:	BRENDA 2.5.1.141
KEGG Enzyme Link:	KEGG2.5.1.141
BioCyc Enzyme Link:	BioCyc 2.5.1.141
ExPASy Enzyme Link:	ExPASy2.5.1.141
EC2PDB Enzyme Link:	EC2PDB 2.5.1.141
ExplorEnz Enzyme Link:	ExplorEnz 2.5.1.141
PRIAM enzyme-specific profiles Link:	PRIAM 2.5.1.141
IntEnz Enzyme Link:	IntEnz 2.5.1.141
MEDLINE Enzyme Link:	MEDLINE 2.5.1.141

RHEA:28070	(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o
RULE(radius=1)	[:1]=[P;H0;+0:2](-[:3])(-[OH;+0:4])-[:5]-[:6]-[O;H0;+0:7]-[CH2;+0:8]-[:9].[CH2;+0:10]=[CH;+0:11]-[:12]1:[:13]:[c;H0;+0:14]2:[:15]3:[c;H0;+0:16]:1-[CH;+0:17]=[C;H0;+0:18]1-[:19]=[:20]-[C;H0;+0:21]4=[N+;H0:22]-1-[:23]-31-[:24]3:[c;H0;+0:25](:[:26]:[:27]:[c;H0;+0:28]:3=[CH;+0:29]-[C;H0;+0:30]3=[N+;H0:31]-1-[C;H0;+0:32](=[CH;+0:33]-2)-[:34]=[:35]-3)=[CH;+0:36]-4.[OH2;+0:37]>>[:9]-[CH2;+0:8]-[CH2;+0:10]-[CH;+0:11](-[OH;+0:4])-[:12]1:[:13]:[c;H0;+0:14]2:[:15]3:[c;H0;+0:16]:1=[CH;+0:17]-[C;H0;+0:18]1=[N+;H0:22]4-[C;H0;+0:21](=[CH;+0:36]-[c;H0;+0:25]5:[:26]:[:27]:[c;H0;+0:28]6:[:24]:5-[:23]-3-4-[N+;H0:31]3=[C;H0;+0:32](-[:34]=[:35]-[C;H0;+0:30]-3=[CH;+0:29]-6)-[CH;+0:33]=2)-[:20]=[:19]-1.[:1]=[P;H0;+0:2](-[:3])(-[OH;+0:37])-[:5]-[:6]-[OH;+0:7]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant.	Glerum DM, Tzagoloff A	1994 Aug 30	8078902
Bacillus subtilis CtaA and CtaB function in haem A biosynthesis.	Svensson B, Lübben M, Hederstedt L	1993 Oct	7968515
Over-expression and characterization of Bacillus subtilis heme O synthase.	Mogi T	2009 May	19204012
Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.	Brown BM, Wang Z, Brown KR, Cricco JA, Hegg EL	2004 Oct 26	15491161
Heme O biosynthesis in Escherichia coli: the cyoE gene in the cytochrome bo operon encodes a protoheme IX farnesyltransferase.	Saiki K, Mogi T, Anraku Y	1992 Dec 30	1336371