EC number:2.5.1.16

Enzyme

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EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.16
Description:Spermidine synthase.
Alternative Name: Putrescine aminopropyltransferase.
Aminopropyltransferase.
Prosite: PDOC01033;
PDB:
PDBScop
Cath: 3.30.160.110; 2.30.140.10; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.16
BRENDA Enzyme Link: BRENDA 2.5.1.16
KEGG Enzyme Link: KEGG2.5.1.16
BioCyc Enzyme Link: BioCyc 2.5.1.16
ExPASy Enzyme Link: ExPASy2.5.1.16
EC2PDB Enzyme Link: EC2PDB 2.5.1.16
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.16
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.16
IntEnz Enzyme Link: IntEnz 2.5.1.16
MEDLINE Enzyme Link: MEDLINE 2.5.1.16

EC number:2.5.1.16

MSA:

2.5.1.16;
Phylogenetic Tree:

2.5.1.16;
Uniprot:
M-CSA:
RHEA:12721 putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH2;+0:6]-[*:7]>>[*:7]-[CH2;+0:6]-[NH;+0:2]-[*:1].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structure and mechanism of spermidine synthases.Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN2007 Jul 1717585781
Crystal structure of Helicobacter pylori spermidine synthase: a Rossmann-like fold with a distinct active site.Lu PK, Tsai JY, Chien HY, Huang H, Chu CH, Sun YJ2007 May 1517357156
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.Burger PB, Birkholtz LM, Joubert F, Haider N, Walter RD, Louw AI2007 Feb 1517196392