EC number:2.5.1.19

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.19
Description:3-phosphoshikimate 1-carboxyvinyltransferase.
Alternative Name: EPSP synthase.
5-enolpyruvylshikimate-3-phosphate synthase.
3-enol-pyruvoylshikimate-5-phosphate synthase.
Prosite: PDOC00097;
PDB:
PDBScop
1RF6 8028163; 8040542; 8028163; 8040542; 8028163; 8040542; 8028163; 8040542;
1RF5 8028163; 8040542; 8028163; 8040542; 8028163; 8040542; 8028163; 8040542;
1RF4 8028163; 8040542; 8028163; 8040542; 8028163; 8040542; 8028163; 8040542;
3FK1 8023397; 8035777;
3FK0 8023397; 8035777;
 » show all
Cath: 1.20.1090.10; 3.20.20.70; 3.65.10.10; 3.40.50.1970;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.19
BRENDA Enzyme Link: BRENDA 2.5.1.19
KEGG Enzyme Link: KEGG2.5.1.19
BioCyc Enzyme Link: BioCyc 2.5.1.19
ExPASy Enzyme Link: ExPASy2.5.1.19
EC2PDB Enzyme Link: EC2PDB 2.5.1.19
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.19
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.19
IntEnz Enzyme Link: IntEnz 2.5.1.19
MEDLINE Enzyme Link: MEDLINE 2.5.1.19

EC number:2.5.1.19

MSA:

2.5.1.19;
Phylogenetic Tree:

2.5.1.19;
Uniprot:
M-CSA:
RHEA:21256 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[C;H0;+0:2](-[*:1])=[*:3].[*:5]-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate.Morell H, Clark MJ, Knowles PF, Sprinson DB1967 Jan 104289188
Substrate synergism and the steady-state kinetic reaction mechanism for EPSP synthase from Escherichia coli.Gruys KJ, Walker MC, Sikorski JA1992 Jun 231344882
Shikimate-3-phosphate binds to the isolated N-terminal domain of 5-enolpyruvylshikimate-3-phosphate synthase.Stauffer ME, Young JK, Evans JN2001 Apr 311300775