EC number:2.5.1.22
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.22 | ||
|---|---|---|---|
| Description: | Spermine synthase. | ||
| Alternative Name: |
Spermidine aminopropyltransferase. | ||
| Prosite: | PDOC01033; | ||
| PDB: |
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| Cath: | 3.30.160.110; 2.30.140.10; 3.40.50.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.22 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.22 |
| KEGG Enzyme Link: | KEGG2.5.1.22 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.22 |
| ExPASy Enzyme Link: | ExPASy2.5.1.22 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.22 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.22 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.22 |
| RHEA:19973 | S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH2;+0:6]-[*:7]>>[*:7]-[CH2;+0:6]-[NH;+0:2]-[*:1].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies of inhibition of rat spermidine synthase and spermine synthase. | Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE | 1980 May 1 | 7396856 |
| Specificity of mammalian spermidine synthase and spermine synthase. | Pegg AE, Shuttleworth K, Hibasami H | 1981 Aug 1 | 6798961 |
| Kinetic properties of spermine synthase from bovine brain. | Pajula RL | 1983 Dec 1 | 6419729 |
| Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain. | Pajula RL, Raina A, Eloranta T | 1979 Nov | 520313 |
| Spermidine biosynthesis. Purification and properties of propylamine transferase from Escherichia coli. | Bowman WH, Tabor CW, Tabor H | 1973 Apr 10 | 4572733 |
| Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine. | Knott JM, Römer P, Sumper M | 2007 Jun 26 | 17560575 |
| Aminopropyltransferases: function, structure and genetics. | Ikeguchi Y, Bewley MC, Pegg AE | 2006 Jan | 16428313 |