EC number:2.5.1.29
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.29 | ||
|---|---|---|---|
| Description: | Geranylgeranyl diphosphate synthase. | ||
| Alternative Name: |
Geranylgeranyl-PP synthetase. Geranylgeranyl-diphosphate synthase. Geranylgeranyl pyrophosphate synthetase. Geranylgeranyl pyrophosphate synthase. Farnesyltranstransferase. Farnesyltransferase. | ||
| Prosite: | PDOC00407; | ||
| PDB: |
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| Cath: | 1.10.600.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.29 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.29 |
| KEGG Enzyme Link: | KEGG2.5.1.29 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.29 |
| ExPASy Enzyme Link: | ExPASy2.5.1.29 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.29 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.29 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.29 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.29 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.29 |
| RHEA:17653 | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = all-trans-geranylgeranyl diphosphate + diphosphate |
| RULE(radius=1) | [C:1]([CH3:2])=[C:3][C:4][O:0].[CH2:5]=[C:6]([CH3:7])[C:8][C:9][O:10][P:11](=[O:12])([O:13])[O:14]>>[C:1]([CH3:2])=[C:3][C:4][CH2:5][C:6]([CH3:7])=[C:8][C:9][O:0].[O:10][P:11](=[O:12])([O:13])[O:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. | Jiang Y, Proteau P, Poulter D, Ferro-Novick S | 1995 Sep 15 | 7665600 |
| Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. | Wang G, Dixon RA | 2009 Jun 16 | 19482937 |
| Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation. | Ye Y, Fujii M, Hirata A, Kawamukai M, Shimoda C, Nakamura T | 2007 Sep | 17596513 |
| The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. | Kavanagh KL, Dunford JE, Bunkoczi G, Russell RG, Oppermann U | 2006 Aug 4 | 16698791 |
| Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase. | Hirooka K, Bamba T, Fukusaki E, Kobayashi A | 2003 Mar 1 | 12437513 |
| Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. | Kuzuguchi T, Morita Y, Sagami I, Sagami H, Ogura K | 1999 Feb 26 | 10026212 |