EC number:2.5.1.34

Enzyme

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EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.34
Description:4-dimethylallyltryptophan synthase.
Alternative Name: Tryptophan dimethylallyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.34
BRENDA Enzyme Link: BRENDA 2.5.1.34
KEGG Enzyme Link: KEGG2.5.1.34
BioCyc Enzyme Link: BioCyc 2.5.1.34
ExPASy Enzyme Link: ExPASy2.5.1.34
EC2PDB Enzyme Link: EC2PDB 2.5.1.34
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.34
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.34
IntEnz Enzyme Link: IntEnz 2.5.1.34
MEDLINE Enzyme Link: MEDLINE 2.5.1.34

EC number:2.5.1.34

MSA:

2.5.1.34;
Phylogenetic Tree:

2.5.1.34;
Uniprot:
M-CSA:
RHEA:14173 dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[OH;+0:2].[*:5]:[c;H0;+0:6](:[*:7])-[CH2;+0:3]-[*:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58.Lee SL, Floss HG, Heinstein P1976 Nov999297
The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis.Tsai HF, Wang H, Gebler JC, Poulter CD, Schardl CL1995 Nov 27488077
Purification and characterization of dimethylallyl tryptophan synthase from Claviceps purpurea.Gebler JC, Poulter CD1992 Jul1605639
Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.Unsöld IA, Li SM2005 May15870460
The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass.Wang J, Machado C, Panaccione DG, Tsai HF, Schardl CL2004 Feb14732265