EC number:2.5.1.39

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.39
Description:4-hydroxybenzoate polyprenyltransferase.
Alternative Name: 4-hydroxybenzoate nonaprenyltransferase.
Prosite: PDOC00727;
PDB:
PDBScop
5YDI 8086462; 8086463; 8086462; 8086463; 8086462; 8086463;
6ARY 8086462; 8086463; 8086462; 8086463;
6ARX 8086462; 8086463; 8086462; 8086463;
5YDJ 8086462; 8086463; 8086462; 8086463;
5YDH 8086462; 8086463; 8086462; 8086463;
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3D structure

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PDB

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5YDI; 6ARY; 6ARX; 5YDJ; 5YDH; 1LLF; 4QWW; 1GZ7; 5FKJ; 4BC0; 4A16; 1MAA; 1C2O; 6FSE; 6FSD; 5OV9; 5HCU; 5FUM; 5FPP; 5FOQ; 5EIH; 5EIE; 5EIA; 5EHZ; 5EHQ; 5EHN; 5DTJ; 5DTI; 4BTL; 4B85; 4B84; 4B83; 4B82; 4B81; 4B80; 4B7Z; 4ARA; 4A23; 3ZLV; 3ZLU; 3ZLT; 3DL7; 3DL4; 2Y2V; 2XUQ; 2XUP; 2XUO; 2XUK; 2XUJ; 2XUI; 2XUH; 2XUG; 2XUF; 2XUD; 2WU4; 2WU3; 2WLS; 2WHR; 2WHQ; 2WHP; 2JGM; 2JGL; 2JGK; 2JGJ; 2JGI; 2JGF; 2JGE; 2JF0; 2JEZ; 2HA7; 2HA6; 2HA5; 2HA4; 2HA3; 2HA2; 2HA0; 2H9Y; 2GYW; 2GYV; 2GYU; 2C0Q; 2C0P; 1Q84; 1Q83; 1N5M; 1J07; 1J06; 1MAH; 1KU6; 1C2B; 1YAJ; 1MX9; 2HRQ; 2H7C; 1MX5; 1MX1; 3K9B; 2HRR; 2DR0; 2DQZ; 1YAH; 1YA8; 1YA4; 5A7H; 5A7G; 5A7F; 4AB1; 1K4Y; 3B3Q; 2XB6; 2WQZ; 6I2T; 6F7Q; 6EZ2; 6ESY; 6ESJ; 6EMI; 5LKR; 5K5E; 5DYY; 5DYW; 5DYT; 4XII; 4TPK; 4AQD; 3O9M; 2WIL; 2PM8; 6QAE; 6QAD; 6QAC; 6QAB; 6QAA; 6I0C; 6I0B; 6EYF; 6EUL; 6EQQ; 6EQP; 6EP4; 5NN0; 4BDS; 4BBZ; 4B0P; 4B0O; 4AXB; 3DKK; 3DJY; 2Y1K; 2XQK; 2XQJ; 2XQI; 2XQG; 2XQF; 2XMG; 2XMD; 2XMC; 2XMB; 2WSL; 2WIK; 2WIJ; 2WIG; 2WIF; 2WID; 2J4C; 1XLW; 1XLV; 1XLU; 1P0Q; 1P0P; 1P0M; 1P0I; 1CLE; 1TRH; 1LPS; 1LPP; 1LPO; 1LPN; 1LPM; 1CRL; 1THG; 1QE3; 1C7J; 1C7I; 6H1A; 6H19; 6H18; 6H0V; 6H0T; 1JMY; 1F6W; 1AQL; 2BCE; 1AKN; 1QON; 1QO9; 1DX4; 6F25; 6CQZ; 6CQY; 6CQX; 6CQW; 6CQV; 6CQU; 6CQT; 5HFA; 5HF9; 5HF8; 5HF6; 5HF5; 5FPQ; 4M0F; 4M0E; 4EY7; 4EY6; 4EY5; 4EY4; 3LII; 6O69; 4PQE; 4EY8; 4BDT; 2X8B; 1F8U; 1B41; 6H14; 6H13; 6H12; 6G4P; 6G4O; 6G4N; 6G4M; 6G1W; 6G1V; 6G1U; 6EZH; 6EZG; 2XI4; 2VT7; 2VT6; 2VJD; 2VJC; 2VJB; 2VJA; 2VA9; 2V98; 2V97; 2V96; 1ZGC; 1W76; 1W75; 6G17; 6FQN; 6FLD; 6EWK; 6EUE; 6EUC; 5NUU; 5NAU; 5NAP; 5IH7; 5EI5; 5EHX; 5E4T; 5E4J; 5E2I; 5DLP; 5BWC; 5BWB; 4X3C; 4W63; 4TVK; 3ZV7; 3M3D; 3I6Z; 3I6M; 3GEL; 2WG2; 2WG1; 2WG0; 2WFZ; 2W6C; 2VQ6; 2J4F; 2J3Q; 2J3D; 2DFP; 2CMF; 2CKM; 2CEK; 2C5G; 2C5F; 2C58; 2BAG; 2ACK; 2ACE; 1ZGB; 1W6R; 1W4L; 1VXR; 1VXO; 1VOT; 1UT6; 1U65; 1SOM; 1QTI; 1QIM; 1QIK; 1QIJ; 1QII; 1QIH; 1QIG; 1QIF; 1QIE; 1QID; 1ODC; 1OCE; 1JJB; 1HBJ; 1H23; 1H22; 1GQS; 1GQR; 1GPN; 1GPK; 1FSS; 1EVE; 1EEA; 1EA5; 1E66; 1E3Q; 1DX6; 1CFJ; 1AX9; 1AMN; 1ACL; 1ACJ; 5XEQ; 5X61; 5V5V; 5THM; 5OJK; 5OJ6; 5FV4; 4BC1; 4ARB; 3VKF; 3RAR; 3BL8; 3BIX; 3BIW; 3BE8; 2Y2U; 2JEY; 2DQY; 2C4H; 1N5R;

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.39
BRENDA Enzyme Link: BRENDA 2.5.1.39
KEGG Enzyme Link: KEGG2.5.1.39
BioCyc Enzyme Link: BioCyc 2.5.1.39
ExPASy Enzyme Link: ExPASy2.5.1.39
EC2PDB Enzyme Link: EC2PDB 2.5.1.39
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.39
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.39
IntEnz Enzyme Link: IntEnz 2.5.1.39
MEDLINE Enzyme Link: MEDLINE 2.5.1.39

EC number:2.5.1.39

MSA:

2.5.1.39;
Phylogenetic Tree:

2.5.1.39;
Uniprot:
M-CSA:
RHEA:17709 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.Kalén A, Appelkvist EL, Chojnacki T, Dallner G1990 Jan 152295606
Plastoquinone-9 biosynthesis in cyanobacteria differs from that in plants and involves a novel 4-hydroxybenzoate solanesyltransferase.Sadre R, Pfaff C, Buchkremer S2012 Mar 1522166075
RHEA:27782 4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Ubiquinone biosynthesis in microorganisms.Meganathan R2001 Sep 2511583838
Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implication.Collins MD, Jones D1981 Jun7022156
RHEA:44504 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.Hayashi K, Ogiyama Y, Yokomi K, Nakagawa T, Kaino T, Kawamukai M201424911838
Endogenous synthesis of coenzyme Q in eukaryotes.Tran UC, Clarke CF2007 Jun17482885
Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa.Ohara K, Yamamoto K, Hamamoto M, Sasaki K, Yazaki K2006 May16501255
Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.Forsgren M, Attersand A, Lake S, Grünler J, Swiezewska E, Dallner G, Climent I2004 Sep 115153069
COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase.Ashby MN, Kutsunai SY, Ackerman S, Tzagoloff A, Edwards PA1992 Feb 251740455
RHEA:44556 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.Hayashi K, Ogiyama Y, Yokomi K, Nakagawa T, Kaino T, Kawamukai M201424911838
Endogenous synthesis of coenzyme Q in eukaryotes.Tran UC, Clarke CF2007 Jun17482885
Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa.Ohara K, Yamamoto K, Hamamoto M, Sasaki K, Yazaki K2006 May16501255
COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase.Ashby MN, Kutsunai SY, Ackerman S, Tzagoloff A, Edwards PA1992 Feb 251740455
RHEA:44560 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.Hayashi K, Ogiyama Y, Yokomi K, Nakagawa T, Kaino T, Kawamukai M201424911838
Endogenous synthesis of coenzyme Q in eukaryotes.Tran UC, Clarke CF2007 Jun17482885
Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa.Ohara K, Yamamoto K, Hamamoto M, Sasaki K, Yazaki K2006 May16501255
RHEA:44564 4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:6](:[*:5]):[*:7].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.Hayashi K, Ogiyama Y, Yokomi K, Nakagawa T, Kaino T, Kawamukai M201424911838
Endogenous synthesis of coenzyme Q in eukaryotes.Tran UC, Clarke CF2007 Jun17482885
Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa.Ohara K, Yamamoto K, Hamamoto M, Sasaki K, Yazaki K2006 May16501255
Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.Forsgren M, Attersand A, Lake S, Grünler J, Swiezewska E, Dallner G, Climent I2004 Sep 115153069