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2. Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

ID:

2.5.1.43

Description:

Nicotianamine synthase.

Prosite:

PDOC51142;

PDB:

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PDB	Click once to unfold,double click to fold. 2JZO; 2JZN; 1VSQ; 1BLE; 1NRZ; 2JZH;

UniProtKB Enzyme Link:	UniProtKB 2.5.1.43
BRENDA Enzyme Link:	BRENDA 2.5.1.43
KEGG Enzyme Link:	KEGG2.5.1.43
BioCyc Enzyme Link:	BioCyc 2.5.1.43
ExPASy Enzyme Link:	ExPASy2.5.1.43
EC2PDB Enzyme Link:	EC2PDB 2.5.1.43
ExplorEnz Enzyme Link:	ExplorEnz 2.5.1.43
PRIAM enzyme-specific profiles Link:	PRIAM 2.5.1.43
IntEnz Enzyme Link:	IntEnz 2.5.1.43
MEDLINE Enzyme Link:	MEDLINE 2.5.1.43

RHEA:16481	3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine
RULE(radius=1)	[:1]-[S+;H0:2](-[:3])-[CH2;+0:4]-[:5].[:6]-[S+;H0:7](-[:8])-[CH2;+0:9]-[:10]-[:11]-[NH2;+0:12].[:13]-[S+;H0:14](-[:15])-[CH2;+0:16]-[:17]-[:18]-[NH2;+0:19]>>[:5]-[CH2;+0:4]-[NH;+0:12]-[:11]-[:10]-[CH2;+0:9]-[N;H0;+0:19]1-[:18]-[:17]-[CH2;+0:16]-1.[:1]-[S;H0;+0:2]-[:3].[:6]-[S;H0;+0:7]-[:8].[:13]-[S;H0;+0:14]-[:15]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The crystallographic structure of thermoNicotianamine synthase with a synthetic reaction intermediate highlights the sequential processing mechanism.	Dreyfus C, Larrouy M, Cavelier F, Martinez J, Pignol D, Arnoux P	2011 May 28	21487608