EC number:2.5.1.44

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.44
Description:Homospermidine synthase.
Cath: 3.30.360.30; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.44
BRENDA Enzyme Link: BRENDA 2.5.1.44
KEGG Enzyme Link: KEGG2.5.1.44
BioCyc Enzyme Link: BioCyc 2.5.1.44
ExPASy Enzyme Link: ExPASy2.5.1.44
EC2PDB Enzyme Link: EC2PDB 2.5.1.44
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.44
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.44
IntEnz Enzyme Link: IntEnz 2.5.1.44
MEDLINE Enzyme Link: MEDLINE 2.5.1.44

EC number:2.5.1.44

MSA:

2.5.1.44;
Phylogenetic Tree:

2.5.1.44;
Uniprot:
M-CSA:
RHEA:18645 2 putrescine = NH4(+) + sym-homospermidine
RULE(radius=1) [*:1]-[CH2;+0:2]-[NH2;+0:3].[*:4]-[NH2;+0:5]>>[*:4]-[NH;+0:5]-[CH2;+0:2]-[*:1].[NH3;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105.Yamamoto S, Nagata S, Kusaba K1993 Jul8407874
Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings.Srivenugopal KS, Adiga PR1980 Aug 157470060
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.Ober D, Hartmann T1999 Dec 2110611289
RHEA:11236 putrescine + spermidine = propane-1,3-diamine + sym-homospermidine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[NH;+0:4]-[CH2;+0:5]-[*:6]>>[*:3]-[NH2;+0:4].[*:1]-[NH;+0:2]-[CH2;+0:5]-[*:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.Ober D, Hartmann T1999 Dec 2110611289