EC number:2.5.1.46
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.46 |
|---|---|
| Description: | Deoxyhypusine synthase. |
| Alternative Name: |
Spermidine dehydrogenase. [eIF-5A]-deoxyhypusine synthase. (4-aminobutyl)lysine synthase. |
| Cath: | 3.40.910.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.46 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.46 |
| KEGG Enzyme Link: | KEGG2.5.1.46 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.46 |
| ExPASy Enzyme Link: | ExPASy2.5.1.46 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.46 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.46 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.46 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.46 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.46 |
| RHEA:33299 | [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[NH;+0:4]-[CH2;+0:5]-[*:6]>>[*:3]-[NH2;+0:4].[*:1]-[NH;+0:2]-[CH2;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A. | Chen KY, Liu AY | 1997 May-Jun | 9285092 |
| Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase. | Wolff EC, Folk JE, Park MH | 1997 Jun 20 | 9188485 |
| Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. | Joe YA, Wolff EC, Park MH | 1995 Sep 22 | 7673224 |
| Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA. | Tao Y, Chen KY | 1995 Oct 13 | 7592594 |
| Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD. | Wolff EC, Park MH, Folk JE | 1990 Mar 25 | 2108161 |
| Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism. | Wolff EC, Wolff J, Park MH | 2000 Mar 31 | 10734052 |
| Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity. | Ober D, Hartmann T | 1999 Nov 5 | 10542236 |
| Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation. | Wolff EC, Park MH | 1999 Jan 15 | 10028184 |
| Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase. | Ober D, Hartmann T | 1999 Dec 21 | 10611289 |