EC number:2.5.1.48

Enzyme

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EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.48
Description:Cystathionine gamma-synthase.
Alternative Name: O-succinylhomoserine synthetase.
O-succinylhomoserine synthase.
O-succinylhomoserine (thiol)-lyase.
O-succinyl-L-homoserine succinate-lyase (adding cysteine).
Homoserine transsuccinylase.
Homoserine O-transsuccinylase.
Cystathionine synthetase.
Cystathionine synthase.
Prosite: PDOC00677;
PDB:
PDBScop
1N8P 8031299; 8043677; 8031299; 8043677; 8031299; 8043677; 8031299; 8043677;
5X30 8022652; 8035032; 8022652; 8035032; 8022652; 8035032; 8022652; 8035032;
5X2Z 8022652; 8035032; 8022652; 8035032; 8022652; 8035032; 8022652; 8035032;
5X2X 8022652; 8035032; 8022652; 8035032; 8022652; 8035032; 8022652; 8035032;
5X2W 8022652; 8035032; 8022652; 8035032; 8022652; 8035032; 8022652; 8035032;
 » show all
Cath: 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.48
BRENDA Enzyme Link: BRENDA 2.5.1.48
KEGG Enzyme Link: KEGG2.5.1.48
BioCyc Enzyme Link: BioCyc 2.5.1.48
ExPASy Enzyme Link: ExPASy2.5.1.48
EC2PDB Enzyme Link: EC2PDB 2.5.1.48
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.48
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.48
IntEnz Enzyme Link: IntEnz 2.5.1.48
MEDLINE Enzyme Link: MEDLINE 2.5.1.48

EC number:2.5.1.48

MSA:

2.5.1.48;
Phylogenetic Tree:

2.5.1.48;
Uniprot:
M-CSA:
RHEA:20397 L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[SH;+0:6]>>[*:1]-[CH2;+0:2]-[S;H0;+0:6]-[*:5].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction