EC number:2.5.1.49
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.49 | ||
|---|---|---|---|
| Description: | O-acetylhomoserine aminocarboxypropyltransferase. | ||
| Alternative Name: |
OAH sulfhydrylase. O-acetylhomoserine sulfhydrolase. O-acetylhomoserine (thiol)-lyase. O-acetyl-L-homoserine sulfhydrolase. O-acetyl-L-homoserine acetate-lyase (adding methanethiol). Methionine synthase. | ||
| Prosite: | PDOC00677; | ||
| PDB: |
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| Cath: | 3.40.50.720; 3.40.640.10; 3.90.1150.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.49 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.49 |
| KEGG Enzyme Link: | KEGG2.5.1.49 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.49 |
| ExPASy Enzyme Link: | ExPASy2.5.1.49 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.49 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.49 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.49 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.49 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.49 |
| RHEA:27822 | hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[SH2;+0:5]>>[*:4]-[CH2;+0:3]-[SH;+0:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product. | Shimizu H, Yamagata S, Masui R, Inoue Y, Shibata T, Yokoyama S, Kuramitsu S, Iwama T | 2001 Sep 10 | 11566369 |
| Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms. | Yamagata S | 1989 Nov-Dec | 2517474 |
| The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination. | Auger S, Yuen WH, Danchin A, Martin-Verstraete I | 2002 Feb | 11832514 |
| RHEA:10048 | methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[SH;+0:6]>>[*:1]-[OH;+0:2].[*:5]-[S;H0;+0:6]-[CH2;+0:3]-[*:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product. | Shimizu H, Yamagata S, Masui R, Inoue Y, Shibata T, Yokoyama S, Kuramitsu S, Iwama T | 2001 Sep 10 | 11566369 |