EC number:2.5.1.54
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.54 |
|---|---|
| Description: | 3-deoxy-7-phosphoheptulonate synthase. |
| Alternative Name: |
Phospho-2-oxo-3-deoxyheptonate aldolase. Phospho-2-keto-3-deoxyheptonic aldolase. Phospho-2-keto-3-deoxyheptonate aldolase. Phospho-2-keto-3-deoxyheptanoate aldolase. Phospho-2-dehydro-3-deoxyheptonate aldolase. KDPH synthetase. KDPH synthase. DS-Mn. DS-Co. DHAP synthase. Deoxy-D-arabino-heptulosonate-7-phosphate synthetase. DAHP synthase. DAH7-P synthase. D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating). D-erythrose-4-phosphate-lyase. 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating). 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase. 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase. 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase. 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase. 2-dehydro-3-deoxy-phosphoheptonate aldolase. |
| Cath: | 3.20.20.70; 3.30.70.1140; 1.20.59.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.54 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.54 |
| KEGG Enzyme Link: | KEGG2.5.1.54 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.54 |
| ExPASy Enzyme Link: | ExPASy2.5.1.54 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.54 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.54 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.54 |
| RHEA:14717 | D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[P;H0;+0:5](=[*:6])(-[*:7])-[*:8].[*:9]-[CH;+0:10]=[O;H0;+0:11].[OH2;+0:12]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:4])-[CH2;+0:3]-[CH;+0:10](-[*:9])-[OH;+0:11].[*:6]=[P;H0;+0:5](-[*:7])(-[*:8])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. | Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ | 2005 Dec 9 | 16288916 |
| Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation. | Hartmann M, Schneider TR, Pfeil A, Heinrich G, Lipscomb WN, Braus GH | 2003 Feb 4 | 12540830 |
| Characterization of a new feedback-resistant 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroF of Escherichia coli. | Jossek R, Bongaerts J, Sprenger GA | 2001 Aug 7 | 11506923 |
| Crystallization and preliminary X-ray analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tyrosine inhibitable) from Saccharomyces cerevisiae. | Schneider TR, Hartmann M, Braus GH | 1999 Sep | 10489454 |
| Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. | Shumilin IA, Kretsinger RH, Bauerle RH | 1999 Jul 15 | 10425687 |