EC number:2.5.1.55
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.55 |
|---|---|
| Description: | 3-deoxy-8-phosphooctulonate synthase. |
| Alternative Name: |
Phospho-2-keto-3-deoxyoctonate aldolase. KDOP synthase. KDO-8-phosphate synthetase. KDO-8-P synthase. 3-deoxyoctulosonic 8-phosphate synthetase. 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase. 3-deoxy-D-manno-octulosonate-8-phosphate synthase. 2-keto-3-deoxy-8-phosphooctonic synthetase. 2-dehydro-3-deoxy-phosphooctonate aldolase. (pyruvate-phosphorylating). 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase |
| Cath: | 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.55 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.55 |
| KEGG Enzyme Link: | KEGG2.5.1.55 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.55 |
| ExPASy Enzyme Link: | ExPASy2.5.1.55 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.55 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.55 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.55 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.55 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.55 |
| RHEA:14053 | D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[P;H0;+0:5](=[*:6])(-[*:7])-[*:8].[O;H0;+0:9]=[CH;+0:10]-[*:11]-[*:12]-[OH;+0:13].[OH2;+0:14]>>[*:1]-[C;H0;+0:2]1(-[OH;+0:4])-[CH2;+0:3]-[CH;+0:10](-[OH;+0:9])-[*:11]-[*:12]-[O;H0;+0:13]-1.[*:6]=[P;H0;+0:5](-[*:7])(-[*:8])-[OH;+0:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases. | Kona F, Xu X, Martin P, Kuzmic P, Gatti DL | 2007 Apr 17 | 17381075 |
| Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility. | Vainer R, Belakhov V, Rabkin E, Baasov T, Adir N | 2005 Aug 19 | 16023668 |
| Functional and biochemical characterization of a recombinant Arabidopsis thaliana 3-deoxy-D-manno-octulosonate 8-phosphate synthase. | Wu J, Patel MA, Sundaram AK, Woodard RW | 2004 Jul 1 | 15070398 |
| Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance. | Kirk AD, Ibrahim MA, Bollinger RR, Dawson DV, Finn OJ | 1992 Feb | 1371194 |
| Arabidopsis 3-deoxy-D-manno-oct-2-ulosonate-8-phosphate synthase: cDNA cloning and expression analyses. | Matsuura K, Miyagawa I, Kobayashi M, Ohta D, Matoh T | 2003 Jul | 12754267 |
| Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme. | Krosky DJ, Alm R, Berg M, Carmel G, Tummino PJ, Xu B, Yang W | 2002 Feb 11 | 11904225 |