EC number:2.5.1.56

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.56
Description:N-acetylneuraminate synthase.
Alternative Name: NeuAc synthase.
N-acetylneuraminic acid synthase.
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating).
(NANA)condensing enzyme.
Cath: 3.20.20.70; 3.90.1210.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.56
BRENDA Enzyme Link: BRENDA 2.5.1.56
KEGG Enzyme Link: KEGG2.5.1.56
BioCyc Enzyme Link: BioCyc 2.5.1.56
ExPASy Enzyme Link: ExPASy2.5.1.56
EC2PDB Enzyme Link: EC2PDB 2.5.1.56
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.56
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.56
IntEnz Enzyme Link: IntEnz 2.5.1.56
MEDLINE Enzyme Link: MEDLINE 2.5.1.56

EC number:2.5.1.56

MSA:

2.5.1.56;
Phylogenetic Tree:

2.5.1.56;
Uniprot:
M-CSA:
RHEA:19273 H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[P;H0;+0:5](=[*:6])(-[*:7])-[*:8].[O;H0;+0:9]=[CH;+0:10]-[*:11]-[*:12]-[OH;+0:13].[OH2;+0:14]>>[*:1]-[C;H0;+0:2]1(-[OH;+0:4])-[CH2;+0:3]-[CH;+0:10](-[OH;+0:9])-[*:11]-[*:12]-[O;H0;+0:13]-1.[*:6]=[P;H0;+0:5](-[*:7])(-[*:8])-[OH;+0:14]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.Komaki E, Ohta Y, Tsukada Y1997 Dec9438985
Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol.Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC2005 Feb 415516336