EnzyMine

Download

EC Tree

2. Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

ID:	2.5.1.57
Description:	N-acylneuraminate-9-phosphate synthase.
Alternative Name:	Sialic acid 9-phosphate synthetase. N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating). N-acetylneuraminate 9-phosphate synthetase. N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase. N-acetylneuraminate 9-phosphate lyase.
Cath:	3.90.1210.10;

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 2.5.1.57
BRENDA Enzyme Link:	BRENDA 2.5.1.57
KEGG Enzyme Link:	KEGG2.5.1.57
BioCyc Enzyme Link:	BioCyc 2.5.1.57
ExPASy Enzyme Link:	ExPASy2.5.1.57
EC2PDB Enzyme Link:	EC2PDB 2.5.1.57
ExplorEnz Enzyme Link:	ExplorEnz 2.5.1.57
PRIAM enzyme-specific profiles Link:	PRIAM 2.5.1.57
IntEnz Enzyme Link:	IntEnz 2.5.1.57
MEDLINE Enzyme Link:	MEDLINE 2.5.1.57

RHEA:13421	an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate
RULE(radius=1)	[:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[P;H0;+0:5](=[:6])(-[:7])-[:8].[O;H0;+0:9]=[CH;+0:10]-[:11]-[:12]-[OH;+0:13].[OH2;+0:14]>>[:1]-[C;H0;+0:2]1(-[OH;+0:4])-[CH2;+0:3]-[CH;+0:10](-[OH;+0:9])-[:11]-[:12]-[O;H0;+0:13]-1.[:6]=[P;H0;+0:5](-[:7])(-[:8])-[OH;+0:14]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.	Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K	2000 Jul 5	10873658