Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.6
Description:Methionine adenosyltransferase.
Alternative Name: S-adenosylmethionine synthetase.
AdoMet synthetase.
Prosite: PDOC00369;
PDB:
PDBScop
4NDN 8088241; 8088242; 8022909; 8022912; 8022913; 8035289; 8035292; 8035293; 8022909; 8022912; 8022913; 8035289; 8035292; 8035293; 8022909; 8022912; 8022913; 8035289; 8035292; 8035293; 8088241; 8088242; 8022909; 8022912; 8022913; 8035289; 8035292; 8035293;
1QM4 8024026; 8024027; 8024029; 8036405; 8036406; 8036408; 8024026; 8024027; 8024029; 8036405; 8036406; 8036408;
1O9T 8024026; 8024027; 8024029; 8036405; 8036406; 8036408; 8024026; 8024027; 8024029; 8036405; 8036406; 8036408;
1O93 8024026; 8024027; 8024029; 8036405; 8036406; 8036408; 8024026; 8024027; 8024029; 8036405; 8036406; 8036408;
1O92 8024026; 8024027; 8024029; 8036405; 8036406; 8036408; 8024026; 8024027; 8024029; 8036405; 8036406; 8036408;
 » show all

Cath: 3.30.300.10; 3.30.300.280; 3.30.300.340;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.6
BRENDA Enzyme Link: BRENDA 2.5.1.6
KEGG Enzyme Link: KEGG2.5.1.6
BioCyc Enzyme Link: BioCyc 2.5.1.6
ExPASy Enzyme Link: ExPASy2.5.1.6
EC2PDB Enzyme Link: EC2PDB 2.5.1.6
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.6
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.6
IntEnz Enzyme Link: IntEnz 2.5.1.6
MEDLINE Enzyme Link: MEDLINE 2.5.1.6
MSA:

2.5.1.6;

Phylogenetic Tree:

2.5.1.6;

Uniprot:
M-CSA:
RHEA:21080 ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine
RULE(radius=1) ([*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[O;H0;+0:9]-[*:10]).[*:11]-[S;H0;+0:12]-[*:13].[OH2;+0:14]>>[*:4]-[CH2;+0:3]-[S+;H0:12](-[*:11])-[*:13].([*:1]-[OH;+0:2].[*:10]-[OH;+0:9]).[*:5]=[P;H0;+0:6](-[*:7])(-[*:8])-[OH;+0:14]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction