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2. Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

ID:	2.5.1.68
Description:	(2Z,6E)-farnesyl diphosphate synthase.
Alternative Name:	Z-farnesyl diphosphate synthase. (Z)-farnesyl diphosphate synthase.
Cath:	3.40.1180.10;

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UniProtKB Enzyme Link:	UniProtKB 2.5.1.68
BRENDA Enzyme Link:	BRENDA 2.5.1.68
KEGG Enzyme Link:	KEGG2.5.1.68
BioCyc Enzyme Link:	BioCyc 2.5.1.68
ExPASy Enzyme Link:	ExPASy2.5.1.68
EC2PDB Enzyme Link:	EC2PDB 2.5.1.68
ExplorEnz Enzyme Link:	ExplorEnz 2.5.1.68
PRIAM enzyme-specific profiles Link:	PRIAM 2.5.1.68
IntEnz Enzyme Link:	IntEnz 2.5.1.68
MEDLINE Enzyme Link:	MEDLINE 2.5.1.68

RHEA:23300	(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate
RULE(radius=1)	[C:1]([CH3:2])=[C:3][C:4][O:0].[CH2:5]=[C:6]([CH3:7])[C:8][C:9][O:10][P:11](=[O:12])([O:13])[O:14]>>[C:1]([CH3:2])=[C:3][C:4][CH2:5][C:6]([CH3:7])=[C:8][C:9][O:0].[O:10][P:11](=[O:12])([O:13])[O:14]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Cloning and functional analysis of novel short-chain cis-prenyltransferases.	Ambo T, Noike M, Kurokawa H, Koyama T	2008 Oct 31	18725204
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.	Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC	2001 Apr 13	11152452
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.	Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ	2000 Oct	11004176