EC number:2.5.1.73

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.73
Description:O-phospho-L-seryl-tRNA:Cys-tRNA synthase.
Alternative Name: SepCysS.
Sep-tRNA:Cys-tRNA synthase.
Cath: 1.10.260.120; 3.30.160.480; 3.30.930.10; 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.73
BRENDA Enzyme Link: BRENDA 2.5.1.73
KEGG Enzyme Link: KEGG2.5.1.73
BioCyc Enzyme Link: BioCyc 2.5.1.73
ExPASy Enzyme Link: ExPASy2.5.1.73
EC2PDB Enzyme Link: EC2PDB 2.5.1.73
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.73
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.73
IntEnz Enzyme Link: IntEnz 2.5.1.73
MEDLINE Enzyme Link: MEDLINE 2.5.1.73

EC number:2.5.1.73

MSA:

2.5.1.73;
Phylogenetic Tree:

2.5.1.73;
Uniprot:
M-CSA:
RHEA:25686 H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[H+;H0:5].[SH2;+0:6]>>[*:1]-[CH2;+0:2]-[SH;+0:6].[*:4]-[OH;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei.Hauenstein SI, Perona JJ2008 Aug 818559341
Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus.Fukunaga R, Yokoyama S2007 Jun 2917512006
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D2006 Dec 1217142313