EC number:2.5.1.74

Enzyme

Download
EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.74
Description:1,4-dihydroxy-2-naphthoate polyprenyltransferase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.74
BRENDA Enzyme Link: BRENDA 2.5.1.74
KEGG Enzyme Link: KEGG2.5.1.74
BioCyc Enzyme Link: BioCyc 2.5.1.74
ExPASy Enzyme Link: ExPASy2.5.1.74
EC2PDB Enzyme Link: EC2PDB 2.5.1.74
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.74
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.74
IntEnz Enzyme Link: IntEnz 2.5.1.74
MEDLINE Enzyme Link: MEDLINE 2.5.1.74

EC number:2.5.1.74

MSA:

2.5.1.74;
Phylogenetic Tree:

2.5.1.74;
Uniprot:
M-CSA:
RHEA:26478 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[c;H0;+0:6](:[*:7])-[C;H0;+0:8](=[*:9])-[OH;+0:10].[H+;H0:11]>>[*:1]-[OH;+0:2].[*:5]:[c;H0;+0:6](:[*:7])-[CH2;+0:3]-[*:4].[*:9]=[C;H0;+0:8]=[O;H0;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli.Suvarna K, Stevenson D, Meganathan R, Hudspeth ME1998 May9573170
Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.Shineberg B, Young IG1976 Jun 29949474
Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions.Saito Y, Ogura K1981 May7275947
RHEA:30099 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli.Suvarna K, Stevenson D, Meganathan R, Hudspeth ME1998 May9573170
Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.Shineberg B, Young IG1976 Jun 29949474
Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions.Saito Y, Ogura K1981 May7275947
RHEA:33211 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44800 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44804 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44808 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44812 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44816 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44820 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[c;H0;+0:8](:[*:9]):[*:10].[H+;H0:11]>>[*:1]-[CH2;+0:2]-[c;H0;+0:8](:[*:9]):[*:10].[*:4]-[OH;+0:3].[*:5]=[C;H0;+0:6]=[O;H0;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction