EC number:2.5.1.78
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.78 |
|---|---|
| Description: | 6,7-dimethyl-8-ribityllumazine synthase. |
| Alternative Name: |
Lumazine synthase. |
| Cath: | 3.40.50.960; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.78 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.78 |
| KEGG Enzyme Link: | KEGG2.5.1.78 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.78 |
| ExPASy Enzyme Link: | ExPASy2.5.1.78 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.78 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.78 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.78 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.78 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.78 |
| RHEA:26152 | (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[CH;+0:4](-[OH;+0:5])-[CH2;+0:6]-[O;H0;+0:7]-[*:8].[*:9]-[NH;+0:10]-[c;H0;+0:11](:[nH;+0:12]:[*:13]):[c;H0;+0:14](:[*:15])-[NH2;+0:16]>>[*:8]-[OH;+0:7].[*:9]-[n;H0;+0:10]1:[c;H0;+0:4](-[CH3;+0:6]):[c;H0;+0:2](-[*:1]):[n;H0;+0:16]:[c;H0;+0:14](:[*:15])-[c;H0;+0:11]:1:[n;H0;+0:12]:[*:13].[OH2;+0:5].[OH2;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. | Mörtl S, Fischer M, Richter G, Tack J, Weinkauf S, Bacher A | 1996 Dec 27 | 8969176 |
| Biosynthesis of riboflavin: structure and mechanism of lumazine synthase. | Bacher A, Fischer M, Kis K, Kugelbrey K, Mörtl S, Scheuring J, Weinkauf S, Eberhardt S, Schmidt-Bäse K, Huber R, Ritsert K, Cushman M, Ladenstein R | 1996 Feb | 8674771 |
| Biosynthesis of riboflavin. Studies on the reaction mechanism of 6,7-dimethyl-8-ribityllumazine synthase. | Kis K, Volk R, Bacher A | 1995 Mar 7 | 7893702 |
| Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. | Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R | 2005 Mar 1 | 15723519 |
| X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons. | Zhang X, Meining W, Fischer M, Bacher A, Ladenstein R | 2001 Mar 9 | 11237620 |