EC number:2.5.1.87
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.87 |
|---|---|
| Description: | diphosphate specific). |
| Alternative Name: |
Rer2p Z-prenyltransferase. Dehydrodolichyl diphosphate synthase 1. |
| Cath: | 3.40.1180.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.87 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.87 |
| KEGG Enzyme Link: | KEGG2.5.1.87 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.87 |
| ExPASy Enzyme Link: | ExPASy2.5.1.87 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.87 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.87 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.87 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.87 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.87 |
| RHEA:53008 | (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate |
| RULE(radius=1) | [C:1]([CH3:2])=[C:3][C:4][O:0].[CH2:5]=[C:6]([CH3:7])[C:8][C:9][O:10][P:11](=[O:12])([O:13])[O:14]>>[C:1]([CH3:2])=[C:3][C:4][CH2:5][C:6]([CH3:7])=[C:8][C:9][O:0].[O:10][P:11](=[O:12])([O:13])[O:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis. | Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A | 1999 Jan | 9858571 |
| Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. | Park EJ, Grabińska KA, Guan Z, Stránecký V, Hartmannová H, Hodaňová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, Hůlková H, Wen R, Kmoch S, Sessa WC | 2014 Sep 2 | 25066056 |
| Precise bacterial polyprenol length control fails in Saccharomyces cerevisiae. | Poznański J, Szkopinska A | 2007 Jun 5 | 17345630 |
| Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis. | Sato M, Fujisaki S, Sato K, Nishimura Y, Nakano A | 2001 Jun | 11442630 |
| Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis. | Cunillera N, Arró M, Forés O, Manzano D, Ferrer A | 2000 Jul 21 | 10908715 |
| Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis. | Oh SK, Han KH, Ryu SB, Kang H | 2000 Jun 16 | 10764783 |