Enzyme

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     2. Transferases
        2.6 Transferring nitrogenous groups
            2.6.1 Transaminases
ID:2.6.1.100
Description:L-glutamine:2-deoxy-scyllo-inosose aminotransferase.
Cath: 3.40.640.10; 3.90.1150.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.6.1.100
BRENDA Enzyme Link: BRENDA 2.6.1.100
KEGG Enzyme Link: KEGG2.6.1.100
BioCyc Enzyme Link: BioCyc 2.6.1.100
ExPASy Enzyme Link: ExPASy2.6.1.100
EC2PDB Enzyme Link: EC2PDB 2.6.1.100
ExplorEnz Enzyme Link: ExplorEnz 2.6.1.100
PRIAM enzyme-specific profiles Link: PRIAM 2.6.1.100
IntEnz Enzyme Link: IntEnz 2.6.1.100
MEDLINE Enzyme Link: MEDLINE 2.6.1.100
MSA:

2.6.1.100;

Phylogenetic Tree:

2.6.1.100;

Uniprot:
M-CSA:
RHEA:34147 2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH;+0:6](-[*:7])-[NH2;+0:8]>>[*:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:4].[*:1]-[CH;+0:2](-[*:3])-[NH2;+0:8]
Reaction
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References

TitleAuthorsDatePubMed ID
Functional characterization of kanB by complementing in engineered Streptomyces fradiae Deltaneo6::tsr.Jnawali HN, Subba B, Liou K, Sohng JK2009 Jun19219581
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB2005 Apr 2115827636
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK2004 Sep 1515313224
First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics--genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inosose aminotransferase genes.Tamegai H, Eguchi T, Kakinuma K2002 Nov12546424
Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine.Huang F, Li Y, Yu J, Spencer JB2002 Dec 712478783
Identification of L-glutamine: 2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans.Tamegai H, Nango E, Kuwahara M, Yamamoto H, Ota Y, Kuriki H, Eguchi T, Kakinuma K2002 Aug12374384