EC number:2.6.1.42

Enzyme

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     2. Transferases
        2.6 Transferring nitrogenous groups
            2.6.1 Transaminases
ID:2.6.1.42
Description:Branched-chain-amino-acid transaminase.
Alternative Name: Transaminase B.
Branched-chain amino acid aminotransferase.
Prosite: PDOC00618;
PDB:
PDBScop
Cath: 3.20.10.10; 3.30.470.10; 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.6.1.42
BRENDA Enzyme Link: BRENDA 2.6.1.42
KEGG Enzyme Link: KEGG2.6.1.42
BioCyc Enzyme Link: BioCyc 2.6.1.42
ExPASy Enzyme Link: ExPASy2.6.1.42
EC2PDB Enzyme Link: EC2PDB 2.6.1.42
ExplorEnz Enzyme Link: ExplorEnz 2.6.1.42
PRIAM enzyme-specific profiles Link: PRIAM 2.6.1.42
IntEnz Enzyme Link: IntEnz 2.6.1.42
MEDLINE Enzyme Link: MEDLINE 2.6.1.42

EC number:2.6.1.42

MSA:

2.6.1.42;
Phylogenetic Tree:

2.6.1.42;
Uniprot:
M-CSA:
RHEA:24813 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH;+0:6](-[*:7])-[NH2;+0:8]>>[*:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:4].[*:1]-[CH;+0:2](-[*:3])-[NH2;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase.Ichihara A, Koyama E1966 Feb5943594
Leucine aminotransferase. II. Purification and characterization.Taylor RT, Jenkins WT1966 Oct 105922965
Transaminase of branched chain amino acids. VI. Purification and properties of the hog brain enzyme.Aki K, Yokojima A, Ichihara A1969 Apr4979711
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.Aki K, Ogawa K, Ichihara A1968 Jun 44968655
Transamination in Escherichia coli.RUDMAN D, MEISTER A1953 Feb13034817
RHEA:24801 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH;+0:6](-[*:7])-[NH2;+0:8]>>[*:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:4].[*:1]-[CH;+0:2](-[*:3])-[NH2;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase.Ichihara A, Koyama E1966 Feb5943594
Leucine aminotransferase. II. Purification and characterization.Taylor RT, Jenkins WT1966 Oct 105922965
Transaminase of branched chain amino acids. VI. Purification and properties of the hog brain enzyme.Aki K, Yokojima A, Ichihara A1969 Apr4979711
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.Aki K, Ogawa K, Ichihara A1968 Jun 44968655
Transamination in Escherichia coli.RUDMAN D, MEISTER A1953 Feb13034817
RHEA:18321 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH;+0:6](-[*:7])-[NH2;+0:8]>>[*:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:4].[*:1]-[CH;+0:2](-[*:3])-[NH2;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase.Ichihara A, Koyama E1966 Feb5943594
Leucine aminotransferase. II. Purification and characterization.Taylor RT, Jenkins WT1966 Oct 105922965
Transaminase of branched chain amino acids. VI. Purification and properties of the hog brain enzyme.Aki K, Yokojima A, Ichihara A1969 Apr4979711
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.Aki K, Ogawa K, Ichihara A1968 Jun 44968655
Transamination in Escherichia coli.RUDMAN D, MEISTER A1953 Feb13034817